Neuropeptidomics of mouse hypothalamus after imipramine treatment reveal somatostatin as a potential mediator of antidepressant effects
Anna Nilsson, Nikolas Stroth, Xiaoqun Zhang, Hongshi Qi, Maria Falth, Karl Skold, Daniel Hoyer, Per E Andren, Per Svenningsson
NEUROPHARMACOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2012
Excessive activation of the hypothalamic-pituitary-adrenal (HPA) axis has been associated with numerous diseases, including depression, and the tricyclic antidepressant imipramine has been shown to suppress activity of the HPA axis. Central hypothalamic control of the HPA axis is complex and involves a number of neuropeptides released from multiple hypothalamic subnuclei. The present study was therefore designed to determine the effects of imipramine administration on the mouse hypothalamus using a peptidomics approach. Among the factors found to be downregulated after acute (one day) or chronic (21 days) imipramine administration were peptides derived from secretogranin 1 (chromogranin B) a..View full abstract
The authors declare that they have no conflict of interest. This work was supported by Vetenskapsradet, Soderberg stiftelse. The funding source had no role in the preparation of the present manuscript.