Journal article

Pelvic nerve injury causes a rapid decrease in expression of choline acetyltransferase and upregulation of c-Jun and ATF-3 in a distinct population of sacral preganglionic neurons

Christopher J Peddie, Janet R Keast

FRONTIERS IN NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2011

Abstract

Autonomic regulation of the urogenital organs is impaired by injuries sustained during pelvic surgery or compression of lumbosacral spinal nerves (e.g., cauda equina syndrome). To understand the impact of injury on both sympathetic and parasympathetic components of this nerve supply, we performed an experimental surgical and immunohistochemical study on adult male rats, where the structure of this complex part of the nervous system has been well defined. We performed unilateral transection of pelvic or hypogastric nerves and analyzed relevant regions of lumbar and sacral spinal cord, up to 4 weeks after injury. Expression of c-Jun, the neuronal injury marker activating transcription factor-3..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council (Australia) Project



Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (Australia) Project Grant #512140 and Senior Research Fellowships #358709 and #632903 to Janet R. Keast.