Journal article
Simulation of quality-adjusted survival in chronic diseases: An application in type 2 diabetes
AJ Hayes, PM Clarke, M Voysey, A Keech
Medical Decision Making | Published : 2011
Abstract
Background. Recent studies have demonstrated that measures of health-related quality of life can predict complications and mortality in patients with diabetes, even after adjustment for clinical risk factors. Methods. The authors developed a simulation model of disease progression in type 2 diabetes to investigate the impact of patient quality of life on lifetime outcomes and its potential response to therapy. Changes in health utility over time are captured as a result of complications and aging. All risk equations, model parameter estimates, and input data were derived from patient-level data from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial. Results. Healthier..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
Received 7 February 2010 from School of Public Health, University of Sydney, NSW, Australia (AJH, PMC) and NHMRC Clinical Trials Centre, University of Sydney, NSW, Australia (MV, AK). Financial support for this study was provided by the National Health & Medical Research Council of Australia, Project Grant No. 512463 and Capacity Building Grant No. 571372. The funding agreement ensured the authors' independence in designing the study, interpreting the data, and writing and publishing the report. PMC was funded from an Australian National Health & Medical Research Council Career Development Award (571122). The FIELD study was supported by a grant from the Laboratoire Fourniers SA, Dijon France (now part of Solway pharmaceuticals) and was coordinated independently by the National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia, and overseen by the study management committee. The authors thank V. Gebski and K. Howard for their comments on the manuscript and the many patients who participated in the FIELD study. Revision accepted for publication 25 March 2011.