Journal article

Immunological and Viral Determinants of Dengue Severity in Hospitalized Adults in Ha Noi, Viet Nam

Annette Fox, Nguyen Minh Hoa Le, Cameron P Simmons, Marcel Wolbers, Heiman FL Wertheim, Thi Khuong Pham, Thi Hai Ninh Tran, Thi Minh Lien Trinh, Thi Lien Nguyen, Vu Trung Nguyen, Duc Hien Nguyen, Jeremy Farrar, Peter Horby, Walter R Taylor, Van Kinh Nguyen



BACKGROUND: The relationships between the infecting dengue serotype, primary and secondary infection, viremia and dengue severity remain unclear. This cross-sectional study examined these interactions in adult patients hospitalized with dengue in Ha Noi. METHODS AND FINDINGS: 158 patients were enrolled between September 16 and November 11, 2008. Quantitative RT-PCR, serology and NS1 detection were used to confirm dengue infection, determine the serotype and plasma viral RNA concentration, and categorize infections as primary or secondary. 130 (82%) were laboratory confirmed. Serology was consistent with primary and secondary infection in 34% and 61%, respectively. The infecting serotype was ..

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University of Melbourne Researchers


Awarded by Wellcome Trust United Kingdom

Awarded by South East Asian Clinical Infectious Disease Network

Funding Acknowledgements

This work was supported by the Wellcome Trust United Kingdom (grant 077078/Z/05/Z). At the time of this study, WT and HW were supported by the South East Asian Clinical Infectious Disease Network (N01-A0-50042). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.