Journal article

Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces

JA Villadangos, P Schnorrer, NS Wilson

IMMUNOLOGICAL REVIEWS | BLACKWELL PUBLISHING | Published : 2005

Abstract

The antigen capturing and presenting abilities of dendritic cells (DCs) are developmentally regulated in a process known as maturation. During maturation, DCs increase several fold their surface expression of major histocompatibility complex class II (MHC II) molecules. This increase is accompanied with a dramatic change in localization of MHC II molecules, which are abundant in endosomal structures in immature DCs but located mostly on the plasma membrane in mature DCs. How these changes relate to antigen processing, generation of MHC II-peptide complexes, and trafficking of MHC II molecules, in the immature and mature states of DC development, has been a matter of debate. Here, we discuss ..

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