Journal article
Failure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile seizures in Chinese patients with epilepsy
C Zhang, V Wong, PW Ng, CHT Lui, NC Sin, KS Wong, L Baum, P Kwan
Epilepsia | WILEY | Published : 2010
Abstract
A recent study in Caucasians found an association between the single nucleotide polymorphism (SNP) of SCN1A, IVS5N +5 G>A (rs3812718), and febrile seizures (FS). We examined whether this and other tagging SNPs of SCN1A were associated with an increased risk of FS in Han Chinese. A total of 728 Han Chinese patients with focal epilepsy were recruited: 97 had a history of FS (58% male, mean age 35 ± 12 years) and 631 did not (50% male, mean age 40 ± 15 years). Genotyping was performed for IVS5N +5 G>A and seven other tagging SNPs selected from the HapMap database. Genotyping was also performed in 848 ethnically matched population controls (50% male, mean age 37 ± 17 years). There was no statist..
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Awarded by Research Grants Council of the Hong Kong Special Administrative Region, China
Funding Acknowledgements
Research Grants Council of the Hong Kong Special Administrative Region, China (Project no. CUHK4466/06M). We would like to thank Drs. Brian Tomlinson and Gary Wong, both of the Chinese University of Hong Kong, for providing some of the DNA samples of the population controls. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. None of the authors has any confl ict of interest to disclose.