Journal article
Epilepsy in later life
MJ Brodie, AT Elder, P Kwan
Lancet Neurology | ELSEVIER SCIENCE INC | Published : 2009
Abstract
Epilepsy is most likely to develop in later life. The burden of this disorder on health-care resources will rise further as the world's population continues to age. Making a secure diagnosis can be challenging because the clinical manifestations of seizures and the differential diagnoses and causes of epilepsy can be different in older individuals compared with younger individuals. Obtaining a reliable account of the events for accurate assessment is particularly important in guiding the appropriate choice and interpretation of investigations to arrive at the correct diagnosis. In older age, unique pharmacokinetic and pharmacodynamic changes occur. The use and selection of antiepileptic drug..
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Funding Acknowledgements
MJB is a consultant for Pfizer, UCB Pharma, Eisai, GlaxoSmithKline, Valeant, Johnson & Johnson, Schwarz Pharma, Sierra Neuropharmaceuticals, Ikano Therapeutics, and Medtronic. He has received research grants from Pfizer, UCB Pharma, and Eisai within the past 3 years. PK has received contracted research grants from Eisai, Johnson & Johnson, Pfizer, and UCB Pharma within the past 3 years. ATE has no conflicts of interest.