Journal article
Gene-wide tagging study of association between ABCB1 polymorphisms and multidrug resistance in epilepsy in Han Chinese
P Kwan, V Wong, PW Ng, CHT Lui, NC Sin, WS Poon, HK Ng, KS Wong, L Baum
Pharmacogenomics | Published : 2009
DOI: 10.2217/pgs.09.32
Abstract
Aims: It remains controversial wether polymorphisms of the multidrug resistance gene ABCB1 are associated with pharmacoresistance in epilepsy. To furtehr study the potential association, we genotyped a broad set of tagging SNPs, and explored whether any associatios were affected by other host factors. We correlated any association with cerebral mRNA expression of ABCB1. Materials & methods: A total of 12 tagging and candidate SNPs of ABCB1 were genotyped in 464 Chinese epilepsy patients (270 drug responsive, 194 drug resistant). Genotype and allele distributions in drug-response and drug-resistant patients were compared. ABCB1 mRNA was quantified by real-time PCR in brain samples resected fr..
View full abstractGrants
Awarded by Research Grants Council of the Hong Kong Special Administrative Region, China
Funding Acknowledgements
The work described in the paper was supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (Project no. CUHK4466/06M). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.