Journal article

Household transmission of respiratory viruses - assessment of viral, individual and household characteristics in a population study of healthy Australian adults

James M McCaw, Peter F Howard, Peter C Richmond, Michael Nissen, Theo Sloots, Stephen B Lambert, Michael Lai, Michael Greenberg, Terry Nolan, Jodie McVernon



BACKGROUND: Household transmission of influenza-like illness (ILI) may vary with viral and demographic characteristics. We examined the effect of these factors in a population-based sample of adults with ILI. METHODS: We conducted a prospective cohort study in community-dwelling Australian adults nested within an influenza vaccine effectiveness trial. On presentation with ILI, participants were swabbed for a range of respiratory viruses and asked to return a questionnaire collecting details of household members with or without similar symptoms. We used logistic and Poisson regression to assess the key characteristics of household transmission. RESULTS: 258 participants from multi-occupancy h..

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Awarded by Australian Research Council (ARC) Linkage Project

Awarded by National Health and Medical Research Council (Australia)'s (NHMRC) Capacity Building Grant

Awarded by ARC Future Fellowship

Awarded by NHMRC Career Development Award

Funding Acknowledgements

We thank study staff at the 12 sites for the recruitment of participants and collection of and processing of samples for this sub-study. We thank Dale Cooper (CSL Limted) for facilitating study conduct including provision of study data collected by CSL as part of the main vaccine study. Jeff Karrasch, William Rawlinson, Helen Marshall, Sepehr Shakib, Fred de Looze, John McBride, Maree O'Sullivan and Walter Abhayaratna led the investigation at participating sites. We thank Dr Julie Simpson for statistical advice. This research was supported by an Australian Research Council (ARC) Linkage Project (LP0989464) with support from CSL Limited, Victoria, Australia, with additional funding from the Murdoch Childrens Research Institute and University of Melbourne, Victoria, Australia. James McCaw received salary support from the National Health and Medical Research Council (Australia)'s (NHMRC) Capacity Building Grant (358425) scheme and an ARC Future Fellowship (FT110100250). Jodie McVernon received salary support from an NHMRC Career Development Award (566635).PCR has previously served on a scientific advisory board regarding influenza vaccines for CSL Ltd and has received a grant for an investigator initiated epidemiological study of otitis media from GlaxoSmithKline Australia. He has also received travel support for himself and staff employed by the Vaccine Trial Group to attend and present data at scientific meetings from Baxter, GlaxoSmithKline, Sanofi and Pfizer.MDN has received travel grants from Wyeth Australia to present independent research at international meetings, and currently and previously has been the principal investigator for clinical trials sponsored by Abbott, Baxter, CSL, GSK, MedImmune, Merck, Novartis, Sanofi-Pasteur, Wyeth, and Pfizer. ML is an employee of CSL Limited and has an equity interest in the company.