Journal article
Loss of Parietal Cell Expression of Sonic Hedgehog Induces Hypergastrinemia and Hyperproliferation of Surface Mucous Cells
C Xiao, SA Ogle, MA Schumacher, MA Orr-Asman, ML Miller, N Lertkowit, A Varro, F Hollande, Y Zavros
Gastroenterology | W B SAUNDERS CO-ELSEVIER INC | Published : 2010
Abstract
Background & Aims: Sonic Hedgehog (Shh) is expressed in the adult stomach, but its role as a gastric morphogen is unclear. We sought to identify mechanisms by which Shh might regulate gastric epithelial cell function and differentiation. Methods: Mice with a parietal cell-specific deletion of Shh (HKCre/ShhKO) were created. Gastric morphology and function were studied in control and HKCre/ShhKO mice between 1 and 8 months of age. Results: In contrast to control mice, HKCre/ShhKO mice developed gastric hypochlorhydria, hypergastrinemia, and a phenotype that resembled foveolar hyperplasia. The fundic mucosa of HKCre/ShhKO mice had an expanded surface pit cell lineage that was documented by inc..
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Awarded by Medical Research Council
Funding Acknowledgements
Supported by start-up funds (Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH) and from the Digestive Health Center Cincinnati Children's Medical Health Center (DHC: Bench to Bedside Research in Pediatric Digestive Disease) Pilot and Feasibility Project Award CHTF/SUB DK078392 (to Y. Z.).