Journal article

Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium

Pauline Bastide, Charbel Darido, Julie Pannequiri, Ralf Kist, Sylvie Robine, Christiane Marty-Double, Frederic Bibeau, Gerd Scherer, Dominique Joubert, Frederic Hollande, Philippe Blache, Philippe Jay

Journal of Cell Biology | Rockefeller University Press | Published : 2007


The HMG-box transcription factor Sox9 is expressed in the intestinal epithelium, specifically, in stem/progenitor cells and in Paneth cells. Sox9 expression requires an active beta-catenin-Tcf complex, the transcriptional effector of the Wnt pathway. This pathway is critical for numerous aspects of the intestinal epithelium physiopathology, but processes that specify the cell response to such multipotential signals still remain to be identified. We inactivated the Sox9 gene in the intestinal epithelium to analyze its physiological function. Sox9 inactivation affected differentiation throughout the intestinal epithelium, with a disappearance of Paneth cells and a decrease of the goblet cell l..

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University of Melbourne Researchers