Journal article

Accuracy of unidimensional and volumetric ultrasound measurements in predicting good pathological response to neoadjuvant chemotherapy in breast cancer patients

I Gounaris, E Provenzano, AL Vallier, L Hiller, M Iddawela, S Hilborne, K Taylor, P Britton, HM Earl, R Sinnatamby

Breast Cancer Research and Treatment | SPRINGER | Published : 2011


Pathological complete response (pCR) is an important predictor of long-term survival in patients with breast cancer receiving neoadjuvant chemotherapy (NAC). At present, the accuracy of traditional radiological assessments during treatment in predicting pCR is poor. Unidimensional and 3D volumetric ultrasound measurements prior to, after 4 cycles (mid-treatment), and at the end of 8 cycles (end-treatment) of chemotherapy were available from a subset of 55 patients enrolled in Neo-tAnGo, a National Cancer Research Network (NCRN) UK neoadjuvant chemotherapy breast cancer trial. Proportional changes in longest diameter (LD) and volume as well as absolute residual size thresholds were examined f..

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University of Melbourne Researchers


Awarded by Cancer Research UK

Funding Acknowledgements

We would like to thank Drs Graham Treece, Richard Prager and Andrew Gee at the Department of Engineering, University of Cambridge who set up the 3D US imaging system and the whole Medical Imaging Group at the department for loaning of the equipment and providing technical support. We would also like to thank Miss Natalie Hicks for assistance with data input. EP, PB, HME and RS are supported with research funding from the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (BMRC).