Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility
Ernesto Vargas, Steven Petrou, Christopher A Reid
JOURNAL OF PHYSIOLOGY-LONDON | WILEY-BLACKWELL | Published : 2013
The expression of Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) is responsible for high intracellular Cl(-) resulting in the excitatory action of GABA(A) receptor activation in the developing brain. Giant depolarizing potentials (GDPs) are spontaneous network oscillations that involve GABA(A) receptors and are thought to be important in establishing neuronal circuit wiring. Earlier work established that seizure susceptibility in the GABA(A) γ2(R43Q) epilepsy mouse is impacted by developmental consequences of impaired GABA(A) receptor function. We investigated the potential mechanism of the developmental influence by recording GDPs in the CA3 pyramidal neurons from brain slices of the neonatal GABA..View full abstract
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Awarded by ARC
This study was supported by NHMRC project grant 628520 to C. A. R., and a NHMRC program grant 400121 to S. P. C. A. R. also acknowledges the support of an ARC Future Fellowship (FT0990628). SP is a NHMRC Senior Research Fellow. The authors have no financial conflict to declare with regards to this research.