Deciphering the syntax of cytotoxic lymphocyte degranulation
Jamie A Lopez, Ilia Voskoboinik
EUROPEAN JOURNAL OF IMMUNOLOGY | WILEY | Published : 2013
In the killer lymphocyte, the targeted delivery of perforin- and granzyme-containing cytotoxic granules to the immunological synapse is crucial for the eradication of pathogen-infected or transformed targets. This process is achieved through a tightly controlled and highly efficient granule exocytosis pathway. Mutations in the granule trafficking proteins Munc13-4, syntaxin 11, Munc18-2 or Rab27 leads to a fatal lapse of immune surveillance and can be manifested as haemophagocytic lymphohistiocytosis in humans. Elucidation of the role of these proteins in exocytic trafficking is pivotal for our understanding of their role in health and disease. In this issue of the European Journal of Immuno..View full abstract
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J.A.L. is supported by a NH&MRC Postdoctoral Training Fellowship, I.V., is supported by a fellowship and grants from the NHM&RC of Australia. We thank Vivien Sutton for critical reading of the manuscript.