Mycoplasma genitalium Incidence, Organism Load, and Treatment Failure in a Cohort of Young Australian Women
Jennifer Walker, Christopher K Fairley, Catriona S Bradshaw, Sepehr N Tabrizi, Jimmy Twin, Marcus Y Chen, Nicole Taylor, Basil Donovan, John M Kaldor, Kathleen McNamee, Eve Urban, Sandra Walker, Marian Currie, Hudson Birden, Francis J Bowden, Jane Gunn, Marie Pirotta, Lyle Gurrin, Veerakathy Harindra, Suzanne M Garland Show all
CLINICAL INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2013
BACKGROUND: Mycoplasma genitalium (MG) is an emerging sexually transmitted infection (STI) that is potentially associated with reproductive tract sequelae in women. This study aimed to estimate MG incidence and treatment failure and provide estimates of organism load in infection. METHODS: 1110 women aged 16-25 years were recruited from primary care clinics in Australia. Women were tested for MG at baseline, 6 months, and 12 months, and MG organism load was measured by quantitative polymerase chain reaction (PCR). MG-positive cases were screened for MG 23S ribosomal RNA (rRNA) gene point mutations shown to confer azithromycin resistance using high-resolution melt following PCR. RESULTS: MG i..View full abstract
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Awarded by Australian National Health and Medical Research Council
This project was funded by the Commonwealth of Australia, as part of the National Chlamydia Targeted Grants, and the Australian National Health and Medical Research Council (grant number 509144).