Journal article

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1

DM Moujalled, WD Cook, T Okamoto, J Murphy, KE Lawlor, JE Vince, DL Vaux

Cell Death & Disease | NATURE PUBLISHING GROUP | Published : 2013


Awarded by NHMRC

Awarded by ARC fellowship

Funding Acknowledgements

This work was funded by NHMRC grants and fellowships 433063, 461221, 541901, 575512, 637342, 1003435, and ARC fellowship FT100100100, and was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. We thank Stephen Hedrick, Michelle Kelliher, and Heinrich Korner for caspase 8, TRADD, FADD, and RIPK1 gene-deleted cell lines and mice, and Mark McKinlay (TetraLogic Pharmaceuticals) for smac-mimetic compound. We would also like to acknowledge Ian Gentle for helping construct the 4HT-inducible FLAG RIPK3 construct.