TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1
DM Moujalled, WD Cook, T Okamoto, J Murphy, KE Lawlor, JE Vince, DL Vaux
Cell Death & Disease | NATURE PUBLISHING GROUP | Published : 2013
Awarded by NHMRC
Awarded by ARC fellowship
This work was funded by NHMRC grants and fellowships 433063, 461221, 541901, 575512, 637342, 1003435, and ARC fellowship FT100100100, and was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. We thank Stephen Hedrick, Michelle Kelliher, and Heinrich Korner for caspase 8, TRADD, FADD, and RIPK1 gene-deleted cell lines and mice, and Mark McKinlay (TetraLogic Pharmaceuticals) for smac-mimetic compound. We would also like to acknowledge Ian Gentle for helping construct the 4HT-inducible FLAG RIPK3 construct.