Journal article

Body weight at early and middle adulthood, weight gain and persistent overweight from early adulthood are predictors of the risk of total knee and hip replacement for osteoarthritis

Yuanyuan Wang, Anita Wluka, Julie A Simpson, Graham G Giles, Stephen E Graves, Richard N de Steiger, Flavia M Cicuttini

RHEUMATOLOGY | OXFORD UNIV PRESS | Published : 2013

Abstract

OBJECTIVES: To examine the relationships between weight at early and middle adulthood and adult weight gain and the risk of total knee and hip replacement for OA. METHODS: At baseline interview during 1990-94, 38,149 participants [mean age 54.9 (S.D. 8.6) years] of the Melbourne Collaborative Cohort Study were asked to recall their weight at age 18-21 years and had their middle age height and weight measured. Total knee and hip replacement for OA between 2001 and 2009 was determined by linking the cohort records to the Australian Orthopaedic Association National Joint Replacement Registry. RESULTS: Greater weight and BMI at age 18-21 years and middle age, weight gain and persistent overweigh..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by capacity building grant


Awarded by NHMRC



Funding Acknowledgements

The recruitment of the Melbourne Collaborative Cohort Study was funded by VicHealth and Cancer Council Victoria. The Melbourne Collaborative Cohort Study was funded by a program grant from the National Health and Medical Research Council (NHMRC; 209057), capacity building grant (251533), and enabling grant (396414), and was further supported by infrastructure provided by Cancer Council Victoria. Dr Wang is the recipient of an Arthritis Australia Fellowship. Dr Wluka is the recipient of NHMRC Career Development Fellowship (Clinical, level 1, #545876).