Fruit and Vegetable Intake and Risk of Breast Cancer by Hormone Receptor Status
Seungyoun Jung, Donna Spiegelman, Laura Baglietto, Leslie Bernstein, Deborah A Boggs, Piet A van den Brandt, Julie E Buring, James R Cerhan, Mia M Gaudet, Graham G Giles, Gary Goodman, Niclas Hakansson, Susan E Hankinson, Kathy Helzlsouer, Pamela L Horn-Ross, Manami Inoue, Vittorio Krogh, Marie Lof, Marjorie L McCullough, Anthony B Miller Show all
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | OXFORD UNIV PRESS INC | Published : 2013
BACKGROUND: Estrogen receptor-negative (ER(-)) breast cancer has few known or modifiable risk factors. Because ER(-) tumors account for only 15% to 20% of breast cancers, large pooled analyses are necessary to evaluate precisely the suspected inverse association between fruit and vegetable intake and risk of ER(-) breast cancer. METHODS: Among 993 466 women followed for 11 to 20 years in 20 cohort studies, we documented 19 869 estrogen receptor positive (ER(+)) and 4821 ER(-) breast cancers. We calculated study-specific multivariable relative risks (RRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression analyses and then combined them using a random-effects model. ..View full abstract
Awarded by National Institute of Health
This work was supported by grants from National Institute of Health (CA55075 to WCW) and the Breast Cancer Research Foundation (to WCW) and the fellowship from Samsung Scholarship (to SJ).