A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration

Ben J Gu; Paul N Baird; Kirstan A Vessey; Kristen K Skarratt; Erica L Fletcher; Stephen J Fuller; Andrea J Richardson; Robyn H Guymer; James S Wiley

Journal article

A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration

Ben J Gu, Paul N Baird, Kirstan A Vessey, Kristen K Skarratt, Erica L Fletcher, Stephen J Fuller, Andrea J Richardson, Robyn H Guymer, James S Wiley

FASEB Journal | FEDERATION AMER SOC EXP BIOL | Published : 2013

DOI: 10.1096/fj.12-215368

University of Melbourne Researchers

James Wiley Author Florey Department of Neuroscience and Mental Health

Erica Fletcher Author Anatomy and Neuroscience

Paul Baird Author Ophthalmology Eye and Ear Hospital

Kirstan Vessey Author Anatomy and Neuroscience

Robyn Guymer Author Ophthalmology Eye and Ear Hospital

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)

Awarded by Centre for Clinical Research Excellence

Awarded by Australian Research Council

Funding Acknowledgements

This study was supported by Australian National Health and Medical Research Council (NHMRC) project grants 1048082, 633275, and 566814; Centre for Clinical Research Excellence grant 529923 (Translational Clinical Research in Major Eye Diseases); an American Health Assistance Foundation, Macular Degeneration Research grant to E. L. F.; Australian Research Council Future Fellowship FT120100581 to B.J.G.; NHMRC Practitioner Fellowship 529905 to R. H. G.; and NHMRC Senior Research Fellowship 1028444 to P.N.B. Centre for Eye Research Australia receives operational infrastructure support from the Victorian government.