AKT signalling is required for ribosomal RNA synthesis and progression of E mu-Myc B-cell lymphoma in vivo

Jennifer R Devlin; Katherine M Hannan; Pui Y Ng; Megan J Bywater; Jake Shortt; Carleen Cullinane; Grant A McArthur; Ricky W Johnstone; Ross D Hannan; Richard B Pearson

Journal article

AKT signalling is required for ribosomal RNA synthesis and progression of E mu-Myc B-cell lymphoma in vivo

Jennifer R Devlin, Katherine M Hannan, Pui Y Ng, Megan J Bywater, Jake Shortt, Carleen Cullinane, Grant A McArthur, Ricky W Johnstone, Ross D Hannan, Richard B Pearson

The FEBS Journal | WILEY-BLACKWELL | Published : 2013

DOI: 10.1111/febs.12135

University of Melbourne Researchers

Grant McArthur Author Melbourne Medical School

Jake Shortt Author The Sir Peter MacCallum Department of Oncology

Richard Pearson Author The Sir Peter MacCallum Department of Oncology

Ricky Johnstone Author The Sir Peter MacCallum Department of Oncology

Katherine Hannan Author Biochemistry and Molecular Biology

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Grants

Awarded by National Health and Medical Research Council of Australia

Awarded by Merck

Funding Acknowledgements

We would like to thank Merck for supplying MK-2206. This work was supported by National Health and Medical Research Council of Australia project grants 1043884, 251608, 566702, 166908, 251688, 509087, 400116, 400120 and 566876. The researchers were funded by National Health and Medical Research Council of Australia fellowships (R. D. H., R. B. P. and R. W. J.), the Cancer Council of Victoria (Sir Edward Weary Dunlop Fellowship to G. A. M.) and the Leukaemia Foundation of Australia (PhD scholarship to J. R. D.). We thank Jeannette Schreuders, Susan Jackson and Rachael Walker for animal technical assistance.