Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies

Abstract

The development and use of combination immunotherapy-based anticancer regimens is at an early but clearly excitingstage. We now demonstrate that the antibody-based co-targeting of multiple immunostimulatory and/or inhibitory pathways can be used safely and effectively in combination with single dose or fractionated radiotherapy to cure mice bearing established mammary tumors. © 2012 Landes Bioscience.