Journal article

Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer

Ratana Lim, Martha Lappas, Clyde Riley, Niels Borregaard, Holger J Moller, Nuzhat Ahmed, Gregory E Rice



UNLABELLED: BACKGROUND: Epithelial ovarian cancer is one of the leading causes of gynaecological cancer morbidity and mortality in women. Early stage ovarian cancer is usually asymptomatic, therefore, is often first diagnosed when it is widely disseminated. Currently available diagnostics lack the requisite sensitivity and specificity to be implemented as community-based screening tests. The identification of additional biomarkers may improve the diagnostic efficiency of multivariate index assays. The aims of this study were to characterise and compare the ovarian tissue immunohistochemical localisation and plasma concentrations of three putative ovarian cancer biomarkers: human cationic an..

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Awarded by NHMRC RD Wright Fellowship

Funding Acknowledgements

BOOTS (Breasts, Ovaries, and Other Things Sacred) and All Inc provided PhD scholarship funding for Ratana Lim. Professor Gregory Rice is a National Health and Medical Research Council (NHMRC) Principal Research Fellow. Dr. Martha Lappas is the recipient of a NHMRC RD Wright Fellowship (Grant No. 454777). Funding for the Leica Qwin Image Analysis System was provided by the Medical Research Foundation for Women and Babies. The authors gratefully acknowledge Professor Michael Quinn, the assistance of Julene Hallo of the Royal Women's Hospital for specimen collection, and the support of the Fight Cancer Foundation and Jigsaw.