Placental Specific mRNA in the Maternal Circulation Are Globally Dysregulated in Pregnancies Complicated by Fetal Growth Restriction
Clare L Whitehead, Susan P Walker, Louie Ye, Sonali Mendis, Tu'uhevaha J Kaitu'u-Lino, Martha Lappas, Stephen Tong
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | ENDOCRINE SOC | Published : 2013
CONTEXT: Fetal growth restriction (FGR) is a leading cause of perinatal mortality, yet no reliable screening test exists. Placental specific mRNA in the maternal circulation may reflect changes in the placental transcriptome in FGR and could be a novel biomarker for FGR. OBJECTIVE: The aim of the study was to identify placental specific RNA detectable in the maternal circulation and examine whether they are differentially expressed in severe preterm FGR. DESIGN: In silico screening was used to identify placental specific RNAs. Their expression in cases of severe FGR vs controls was examined in both maternal blood and placenta by microarray, RT-PCR, and in situ hybridization. RESULTS: Via in ..View full abstract
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Awarded by NHMRC fellowship
Awarded by NHMRC Career Development Fellowship
This project was funded by a Royal Australian and New Zealand College of Obstetricians and Gynecologists Arthur Wilson Scholarship, a William Buckland Foundation Grant, a Medical Research Foundation for Women and Babies Grant, and a National Health and Medical Research Council (NHMRC) Project Grant (no. 1028521). T.J.K.-L. is supported by a NHMRC fellowship (no. 490995), and S.T. is supported by a NHMRC Career Development Fellowship (no. 490870).