Placental specific mRNA in the maternal circulation are globally dysregulated in pregnancies complicated by fetal growth restriction

CL Whitehead; SP Walker; L Ye; S Mendis; TJ Kaitu'u-Lino; M Lappas; S Tong

Journal article

Placental specific mRNA in the maternal circulation are globally dysregulated in pregnancies complicated by fetal growth restriction

CL Whitehead, SP Walker, L Ye, S Mendis, TJ Kaitu'u-Lino, M Lappas, S Tong

Journal of Clinical Endocrinology and Metabolism | ENDOCRINE SOC | Published : 2013

DOI: 10.1210/jc.2012-2468

Abstract

Context: Fetal growth restriction (FGR) is a leading cause of perinatal mortality, yet no reliable screening test exists. Placental specific mRNAin the maternal circulation may reflect changes in the placental transcriptome in FGR and could be a novel biomarker for FGR. Objective: The aim of the study was to identify placental specific RNA detectable in the maternal circulation and examine whether they are differentially expressed in severe preterm FGR. Design: In silico screening was used to identify placental specific RNAs. Their expression in cases of severe FGR vs controls was examined in both maternal blood and placenta by microarray, RT-PCR, and in situ hybridization. Results: Via in s..

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University of Melbourne Researchers

Clare Whitehead Author

Susan Walker Author

Tu'uhevaha Kaitu'u-Lino Author

Martha Lappas Author

Related Projects (2)

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Grants

Awarded by NHMRC fellowship

Awarded by NHMRC Career Development Fellowship

Funding Acknowledgements

This project was funded by a Royal Australian and New Zealand College of Obstetricians and Gynecologists Arthur Wilson Scholarship, a William Buckland Foundation Grant, a Medical Research Foundation for Women and Babies Grant, and a National Health and Medical Research Council (NHMRC) Project Grant (no. 1028521). T.J.K.-L. is supported by a NHMRC fellowship (no. 490995), and S.T. is supported by a NHMRC Career Development Fellowship (no. 490870).