Journal article
Targeting Dendritic Cells: The Role of Specific Receptors in the Internalization of Polymer Capsules
JD Mintern, C Percival, MMJ Kamphuis, WJ Chin, F Caruso, APR Johnston
Advanced Healthcare Materials | Published : 2013
Abstract
Dendritic cells (DCs) are an important target for vaccine delivery. It is shown that antibody functionalized polymer capsules can effectively target DCs; however, the internalization is highly dependent on the specific receptor targeted. This work highlights the importance of considering factors such as how the antibody/capsule is internalized, rather than just the target specificity.
Grants
Funding Acknowledgements
This work was supported by the Australian Research Council under the Future Fellowship (A.P.R.J), Federation Fellowship (F.C.) and Discovery Project (A.P.R.J.; F.C.) schemes and N.H.M.R.C. (Australia) Career Development Fellowship (J.D.M)