Journal article

Mapping brain activity using event-related independent components analysis (eICA): Specific advantages for EEG-fMRI

Richard AJ Masterton, Graeme D Jackson, David F Abbott



Event-related analyses of functional MRI (fMRI) typically assume that the onset and offset of neuronal activity match stimuli onset and offset, and that evoked fMRI signal changes follow the canonical haemodynamic response function (HRF). Some event types, however, may be unsuited to this approach: brief stimuli might elicit an extended neuronal response; anticipatory effects might result in activity preceding the event; or altered neurovascular coupling may result in a non-canonical HRF. An example is interictal epileptiform discharges (IEDs), which may show a non-canonical HRF and fMRI signal changes preceding their onset as detected on EEG. In such cases, less constrained analyses - capab..

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Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

We thank the patients and their families for participation in this work; Leasha Lilywhite, Danny Flanagan, Simon Harvey, Ingrid Scheffer and John Archer for patient recruitment, neurophysiological and phenotyping assistance. Funding was received from the National Health and Medical Research Council of Australia Program grant 628952 and practitioner fellowship 527800 to GDJ, and from the Operational Infrastructure Support Program of the State Government of Victoria, Australia.