Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion
Neel Sengupta, Christopher Yau, Anuratha Sakthianandeswaren, Dmitri Mouradov, Peter Gibbs, Nirosha Suraweera, Jean-Baptiste Cazier, Guadalupe Polanco-Echeverry, Anil Ghosh, Mohamed Thaha, Shafi Ahmed, Roger Feakins, David Propper, Sina Dorudi, Oliver Sieber, Andrew Silver, Cecilia Lai
MOLECULAR CANCER | BMC | Published : 2013
BACKGROUND: Prevalence of colorectal cancer (CRC) in the British Bangladeshi population (BAN) is low compared to British Caucasians (CAU). Genetic background may influence mutations and disease features. METHODS: We characterized the clinicopathological features of BAN CRCs and interrogated their genomes using mutation profiling and high-density single nucleotide polymorphism (SNP) arrays and compared findings to CAU CRCs. RESULTS: Age of onset of BAN CRC was significantly lower than for CAU patients (p=3.0 x 10-5) and this difference was not due to Lynch syndrome or the polyposis syndromes. KRAS mutations in BAN microsatellite stable (MSS) CRCs were comparatively rare (5.4%) compared to CAU..View full abstract
Awarded by UK Medical Research Council
Awarded by Medical Research Council
This work was supported by Barts and The London Charity. Neel Sengupta is supported by a Bowel and Cancer Research clinical fellowship. Christopher Yau is supported by a UK Medical Research Council Special Training Fellowship in Biomedical Informatics (Ref. No. G0701810), Nirosha Suraweera is a Barts and The London Charity UK post-doctoral fellow and Anil Ghosh is a Constance Travis Clinical Fellow.