Journal article
Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion
N Sengupta, C Yau, A Sakthianandeswaren, D Mouradov, P Gibbs, N Suraweera, JB Cazier, G Polanco-Echeverry, A Ghosh, M Thaha, S Ahmed, R Feakins, D Propper, S Dorudi, O Sieber, A Silver, C Lai
Molecular Cancer | Published : 2013
Open access
Abstract
Background: Prevalence of colorectal cancer (CRC) in the British Bangladeshi population (BAN) is low compared to British Caucasians (CAU). Genetic background may influence mutations and disease features.Methods: We characterized the clinicopathological features of BAN CRCs and interrogated their genomes using mutation profiling and high-density single nucleotide polymorphism (SNP) arrays and compared findings to CAU CRCs.Results: Age of onset of BAN CRC was significantly lower than for CAU patients (p=3.0 x 10-5) and this difference was not due to Lynch syndrome or the polyposis syndromes. KRAS mutations in BAN microsatellite stable (MSS) CRCs were comparatively rare (5.4%) compared to CAU M..
View full abstractGrants
Awarded by UK Research and Innovation
Funding Acknowledgements
This work was supported by Barts and The London Charity. Neel Sengupta is supported by a Bowel and Cancer Research clinical fellowship. Christopher Yau is supported by a UK Medical Research Council Special Training Fellowship in Biomedical Informatics (Ref. No. G0701810), Nirosha Suraweera is a Barts and The London Charity UK post-doctoral fellow and Anil Ghosh is a Constance Travis Clinical Fellow.