Journal article
RegR virulence regulon of rabbit-specific enteropathogenic Escherichia coli strain E22
YN Srikhanta, DM Hocking, J Praszkier, MJ Wakefield, RM Robins-Browne, J Yang, M Tauschek
Infection and Immunity | Published : 2013
DOI: 10.1128/IAI.01325-12
Abstract
AraC-like regulators play a key role in the expression of virulence factors in enteric pathogens, such as enteropathogenic Escherichia coli (EPEC), enterotoxigenic E. coli, enteroaggregative E. coli, and Citrobacter rodentium. Bioinformatic analysis of the genome of rabbit-specific EPEC (REPEC) strain E22 (O103:H2) revealed the presence of a gene encoding an AraC-like regulatory protein, RegR, which shares 71% identity to the global virulence regulator, RegA, of C. rodentium. Microarray analysis demonstrated that RegR exerts 25- to 400-fold activation on transcription of several genes encoding putative virulence-associated factors, including a fimbrial operon (SEF14), a serine protease, and ..
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Funding Acknowledgements
This work was supported by grants from the Australian National Health & Medical Research Council (NHMRC), the NHMRC Independent Research Institutes Infrastructure Support Scheme, and the Victorian State Government Operational Infrastructure Support Program to the Murdoch Childrens Research Institute. M.T. and Y.S. were recipients of an NHMRC Peter Doherty Australian Biomedical Fellowship.