Journal article
Mesoporous europo-gadolinosilicate nanoparticles as bimodal medical imaging agents and a potential theranostic platform
NMK Tse, DF Kennedy, N Kirby, BA Moffat, BW Muir, RA Caruso, CJ Drummond
Advanced Healthcare Materials | Published : 2013
Abstract
The mesoporous structure of sol-gel prepared gadolinium and europium doped silicate nanoparticles has been found to be highly dependent on the formulated composition, with synthesised samples displaying both disordered and hexagonally ordered mesoporous packing symmetry. The degree of pore ordering within the nanoparticles has a strong correlation with the total lanthanide (Gd3+ and Eu3+) concentration. The gadolinosilicates are excellent magnetic resonance imaging (MRI) longitudinal (T1) agents. The longitudinal relaxivity (r1) and transverse (r2) relaxivity, a measure of MRI contrast agent efficiency, were up to four times higher than the clinically employed Omniscan (gadodiamide); with r1..
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Awarded by Australian Research Council Future Fellowship
Funding Acknowledgements
The authors thank Chris Sheedy (CSIRO Process Science and Engineering) for performing the ICP-OES analyses, Dr. Sergey Rubanov and staff of the Electron Microscopy Unit at the Bio21 Institute of The University of Melbourne for assisting with the TEM characterization. Portions of this research were undertaken on the SAXS/WAXS beamline at the Australian Synchrotron, Victoria, Australia. N.M.K.T. was the recipient of a CSIRO PhD studentship, D.F.K. was the recipient of a CSIRO Office of the Chief Executive postdoctoral award, R.A.C acknowledges an Australian Research Council Future Fellowship (FT0990583), and C.J.D. was the recipient of an Australian Research Council Federation Fellowship.