Description of technique and lower reference limit for magnetic resonance imaging of hippocampal volumetry in dogs

Abstract

Objective-To evaluate the use of high-resolution MRI for hippocampal volumetry in dogs and to define a lower reference limit for hippocampal formation (HF) volume. Animals-20 dogs (with no history of seizures and no underlying structural brain disease) that underwent MRI of the brain. Procedures-The MRI protocol included a high-resolution T1-weighted 3-D ultrafast gradient- echo sequence aligned in a dorsal plane perpendicular to the long axis of the HF. Images obtained with MRI were retrospectively analyzed by 2 observers (A and B). Intraobserver and interobserver agreement were calculated with the Lin concordance correlation coefficient. Volume measurements of the HF were adjusted for intr..