Bilateral Posterior Periventricular Nodular Heterotopia: A Recognizable Cortical Malformation with a Spectrum of Associated Brain Abnormalities
SA Mandelstam, RJ Leventer, A Sandow, G McGillivray, M van Kogelenberg, R Guerrini, S Robertson, SF Berkovic, GD Jackson, IE Scheffer
AMERICAN JOURNAL OF NEURORADIOLOGY | AMER SOC NEURORADIOLOGY | Published : 2013
BACKGROUND AND PURPOSE: Bilateral posterior PNH is a distinctive complex malformation with imaging features distinguishing it from classic bilateral PNH associated with FLNA mutations. The purpose of this study was to define the imaging features of posterior bilateral periventricular nodular heterotopia and to determine whether associated brain malformations suggest specific subcategories. MATERIALS AND METHODS: We identified a cohort of 50 patients (31 females; mean age, 13 years) with bilateral posterior PNH and systematically reviewed and documented associated MR imaging abnormalities. Patients were negative for mutations of FLNA. RESULTS: Nodules were often noncontiguous (n = 28) and asy..View full abstract
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This paper was funded by a grant from the National Health and Research Council of Australia.