Journal article

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

Kylie D Mason, Ann Lin, Lorraine Robb, Emma C Josefsson, Katya J Henley, Daniel HD Gray, Benjamin T Kile, Andrew W Roberts, Andreas Strasser, David CS Huang, Paul Waring, Lorraine A O'Reilly

Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2013


Awarded by National Health and Medical Research Council (NHMRC) [Canberra]

Awarded by NHMRC

Awarded by Leukemia and Lymphoma Society [Specialized Centre of Research (SCOR)

Awarded by National Institutes of Health


Funding Acknowledgements

We thank C. Thompson (Memorial Sloan-Kettering Cancer Center, New York) for bak<SUP>-/-</SUP> mice; the late S. Korsmeyer (Harvard University) for bax<SUP>-/-</SUP> mice; L. Lee for technical assistance; G. Siciliano, J. Coughlin, K. McKenzie, F. Dabrowski, S. Ross, S. Green, C. Evans, K. Trueman, E. Lanera, H. Donatucci, and D. Cooper for animal care; J. Corbin for automated blood analysis; B. Helbert, C. Young, and A. Georgiou for genotyping; and S. Mihajlovic, E. Tsui, A. Hasanein, V. Babo, and K. Weston for preparation of histological sections. This work was supported by fellowships and grants from the National Health and Medical Research Council (NHMRC) [Canberra; programs 461221, 461219, fellowships; Australia Fellowship (to A.S.), 637353 (to D.H.D.G.), 516701; and Project Grant 637309 (to A.W.R.), 575535 (to B.T.K.), 637332 (to D.H.D.G.), and 1009145 (to L.A.O.)], an NHMRC infrastructure grant, Independent Research Institutes Infrastructure Support Scheme Grant 361646, the Victorian State Government Operational Infrastructure Support (OIS) grant, the Leukemia and Lymphoma Society [Specialized Centre of Research (SCOR) Grant 7413, fellowship to E.C.J.], National Institutes of Health Grants CA043540-18 and CA80188-6, the Juvenile Diabetes Research Fund (JDRF)/NHMRC (A.S.), the Association for International Cancer Research, the Victorian Cancer Agency (K.D.M. and A.W.R.), the Australian Cancer Research Foundation, the Sylvia and Charles Viertel Charitable Foundation, and the Leukemia Foundation Australia (B.T.K.).