Journal article
Widespread decreases in cortical muscarinic receptors in a subset of people with schizophrenia
AS Gibbons, E Scarr, S Boer, T Money, WJ Jeon, C Felder, B Dean
International Journal of Neuropsychopharmacology | Published : 2013
Abstract
These studies were undertaken to investigate the selectivity of cortical muscarinic receptor radioligand binding in muscarinic M1 and M4 receptor knockout mice and to determine whether a marked decrease in [ 3H]pirenzepine binding in Brodmann's area (BA) 9 from a subset of people with schizophrenia was predictive of decreased muscarinic receptors in other central nervous system (CNS) regions. Our data show that, under the conditions used, [3H]pirenzepine binding was highly selective for the muscarinic M1 receptor whereas both [3H]AF-DX 386 and [ 3H]4DAMP had less discriminatory power. In addition, the data suggest that a marked decrease in [3H]pirenzepine binding in BA 9 from a subset of peo..
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Funding Acknowledgements
The authors gratefully acknowledge the assistance of Geoffrey Pavey for the preparation of post-mortem tissue, Susan Juzva, Sam Peyton and Paul Canham for their technical assistance and David Copolov, Christine Hill, Nicholas Keks and Kenneth Opeskin for their roles in tissue collection and diagnostic confirmation. Tissues were received from the Victorian Brain Bank Network, supported by the Mental Health Research Institute, Alfred Hospital, Victorian Forensic Institute of Medicine, The University of Melbourne and funded by Australia's National Health & Medical Research Council, Helen Macpherson Smith Trust, Parkinson's Victoria and Perpetual Philanthropic Services. B.D. is the recipient of a NHMRC Senior Research Fellowship and E.S. is a recipient of an ARC Future Fellowship. The study was supported by Operational Infrastructure Support from the Victorian State Government.