Journal article
Prediagnosis biomarkers of insulin-like growth factor-1, insulin, and interleukin-6 dysregulation and multiple myeloma risk in the Multiple Myeloma Cohort Consortium
BM Birmann, ML Neuhouser, B Rosner, D Albanes, JE Buring, GG Giles, Q Lan, IM Lee, MP Purdue, N Rothman, G Severi, JM Yuan, KC Anderson, M Pollak, N Rifai, P Hartge, O Landgren, L Lessin, J Virtamo, RB Wallace Show all
Blood | AMER SOC HEMATOLOGY | Published : 2012
Abstract
Insulin-like growth factor-1 (IGF-1), insulin, and IL-6 are dysregulated in multiple myeloma pathogenesis and may also contribute to multiple myeloma etiology. To examine their etiologic role, we prospectively analyzed concentrations of serologic markers in 493 multiple myeloma cases and 978 controls from 8 cohorts in the Multiple Myeloma Cohort Consortium. We computed odds ratios (ORs) and 95% confidence intervals (CIs) for multiple myeloma per 1-SD increase in biomarker concentration using conditional logistic regression. We examined heterogeneity by time since blood collection (≤ 3, 4- ≤ 6, and > 6 years) in stratified models. Fasting IGF binding protein-1 concentration was associated wit..
View full abstractGrants
Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by the National Institutes of Health (R01 CA127435, K07 CA115687, B.M.B.; P01 CA87969, R01 CA49449, P01 CA055075, P50 CA100707, CA047988, HL043851, HL080467, R01CA080205, and R01CA144034) and the National Cancer Institute Division of Cancer Epidemiology and Genetics (intramural funds). The WHI program is supported by the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services (contracts N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, and 44221).