Extent of disease on high-resolution computed tomography lung is a predictor of decline and mortality in systemic sclerosis-related interstitial lung disease
Owen A Moore, Nicole Goh, Tamera Corte, Hannah Rouse, Oliver Hennessy, Vivek Thakkar, Jillian Byron, Joanne Sahhar, Janet Roddy, Eli Gabbay, Peter Youssef, Peter Nash, Jane Zochling, Susanna M Proudman, Wendy Stevens, Mandana Nikpour
RHEUMATOLOGY | OXFORD UNIV PRESS | Published : 2013
OBJECTIVES: In a multi-centre study, we sought to determine whether extent of disease on high-resolution CT (HRCT) lung, reported using a simple grading system, is predictive of decline and mortality in SSc-related interstitial lung disease (SSc-ILD), independently of pulmonary function tests (PFTs) and other prognostic variables. METHODS: SSc patients with a baseline HRCT performed at the time of ILD diagnosis were identified. All HRCTs and PFTs performed during follow-up were retrieved. Demographic and disease-related data were prospectively collected. HRCTs were graded according to the percentage of lung disease: >20%: extensive; 20%) on HRCT at baseline, reported using a semi-quantitativ..View full abstract
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This work was supported by a University of Melbourne Early Career Research Grant (M.N. and O.A.M.); Scleroderma Australia; Arthritis Australia; Actelion Australia; Bayer; CSL Biotherapies; GlaxoSmithKline Australia; and Pfizer.