Journal article

HBV-related hepatocellular carcinoma: the role of integration, viral proteins and miRNA

Lucy Lim, Manh Tran Bang, Elizabeth Vincan, Stephen Locarnini, Nadia Warner

FUTURE VIROLOGY | FUTURE MEDICINE LTD | Published : 2012

Abstract

The development of hepatocellular carcinoma during chronic hepatitis B infection is a multifactorial process thought to be a consequence of several direct and indirect mechanisms. In this review we discuss how viral proteins and cycles of ongoing liver damage and regeneration, coupled with HBV DNA integration and aberrant miRNA expression may enhance the risk for the development of hepatocellular carcinoma. © 2012 Future Medicine Ltd.

Grants

Awarded by NHMRC


Funding Acknowledgements

N Warner is supported by NHMRC research grant 1011024. L Lim is supported by Gastroenterological Society of Australia (GESA) postgraduate scholarship. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.