Journal article
The role of partially hydrolyzed whey formula for the prevention of allergic disease: Evidence and gaps
AJ Lowe, SC Dharmage, KJ Allen, ML Tang, DJ Hill
Expert Review of Clinical Immunology | TAYLOR & FRANCIS LTD | Published : 2013
DOI: 10.1586/eci.12.80
Abstract
Hydrolyzed formulae are created by using enzymatic processes to break native proteins into smaller fragments. They may prevent development of allergic diseases by reducing exposure to intact allergens. Partially hydrolyzed whey formula (pHWF) is particularly promising for allergy prevention, as it is cheap to manufacture and palatable. Scientific organizations have recommended the use of hydrolyzed formula in the first 4-6 months of life for the prevention of allergic disease based on a limited number of trials. Three recent developments challenge these recommendations: our growing understanding of the importance of allergen exposure for induction of immune tolerance, recently published evid..
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Funding Acknowledgements
AJ Lowe was previously supported by Dairy Australia, CRC for Asthma & Airways and VicHealth. Currently, AJ Lowe and SC Dharmage are supported by the Australian National Health & Medical Research Council. KJ Allen is funded by a Vietel Senior Medical Research Fellowship, and has received speaker fees from Abbott, Nutricia and Pfizer. DJ Hill has received support from Nutricia, SHS International and Nestle for research and has presented lectures at sponsored meetings. MLK Tang is a member of Medical Advisory Boards for Nestle Nutrition Institute and Nutricia, has sat on advisory committees for Pfizer, and has received payment for speaking engagements with Danone. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.