A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

AA Al Olama; Z Kote-Jarai; FR Schumacher; F Wiklund; SI Berndt; S Benlloch; GG Giles; G Severi; DE Neal; FC Hamdy; JL Donovan; DJ Hunter; BE Henderson; MJ Thun; M Gaziano; EL Giovannucci; A Siddiq; RC Travis; DG Cox; F Canzian; E Riboli; TJ Key; G Andriole; D Albanes; RB Hayes; J Schleutker; A Auvinen; TLJ Tammela; M Weischer; JL Stanford; EA Ostrander; C Cybulski; J Lubinski; SN Thibodeau; DJ Schaid; KD Sorensen; J Batra; JA Clements; S Chambers; J Aitken; RA Gardiner; C Maier; W Vogel; T Dörk; H Brenner; T Habuchi; S Ingles; EM John; JL Dickinson; L Cannon-Albright; MR Teixeira; R Kaneva; HW Zhang; YJ Lu; JY Park; KA Cooney; KR Muir; DA Leongamornlert; E Saunders; M Tymrakiewicz; N Mahmud; M Guy; K Govindasami; LT O'Brien; RA Wilkinson; AL Hall; EJ Sawyer; T Dadaev; J Morrison; DP Dearnaley; A Horwich; RA Huddart; VS Khoo; CC Parker; N Van As; CJ Woodhouse; A Thompson; T Dudderidge; C Ogden; CS Cooper; A Lophatonanon; MC Southey; JL Hopper; D English; J Virtamo; LL Marchand; D Campa; R Kaaks; S Lindstrom; WR Diver; S Gapstur; M Yeager; A Cox; MC Stern; R Corral; M Aly; W Isaacs; J Adolfsson; J Xu; SL Zheng

Journal article

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

AA Al Olama, Z Kote-Jarai, FR Schumacher, F Wiklund, SI Berndt, S Benlloch, GG Giles, G Severi, DE Neal, FC Hamdy, JL Donovan, DJ Hunter, BE Henderson, MJ Thun, M Gaziano, EL Giovannucci, A Siddiq, RC Travis, DG Cox, F Canzian Show all

Human Molecular Genetics | Published : 2013

DOI: 10.1093/hmg/dds425

Abstract

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significantSNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an ass..

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University of Melbourne Researchers

Graham Giles Author

Melissa Southey Author

Dallas English Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This work was supported by Cancer Research UK grants (grant numbers: C5047/A7357, C1287/A10118, C5047/A3354, C5047/A10692, C16913/A6135) and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant (grant number: 1 U19 CA 148537-01 (the GAME-ON initiative)). Further support is detailed in Supplementary Material, Notes.