Journal article

Inflammatory and Haematological Markers in the Maternal, Umbilical Cord and Infant Circulation in Histological Chorioamnionitis

Rebecca A Howman, Adrian K Charles, Angela Jacques, Dorota A Doherty, Karen Simmer, Tobias Strunk, Peter C Richmond, Catherine H Cole, David P Burgner

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2012

Abstract

BACKGROUND: The relationship between histological chorioamnionitis and haematological and biochemical markers in mothers and infants at delivery, and in infants postnatally, is incompletely characterised. These markers are widely used in the diagnosis of maternal and neonatal infection. Our objective was to investigate the effects of histological chorioamnionitis (HCA) on haematological and biochemical inflammatory markers in mothers and infants at delivery, and in infants post-delivery. METHODS: Two hundred and forty seven mothers, delivering 325 infants, were recruited at the only tertiary perinatal centre in Western Australia. Placentae were assessed for evidence of HCA using a semi-quant..

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Grants

Awarded by National Health and Medical Research Council Australia


Awarded by Deutsche Forschungsgemeinschaft


Funding Acknowledgements

The project was funded by Princess Margaret Hospital Foundation, Women and Infant's Research Foundation Western Australia, Clive and Vera Ramaciotti Medical Research Foundation, University of Western Australia, Rebecca Cooper Medical Research Foundation, Channel 7 Telethon, European Society for Paediatric Infectious Diseases and the National Health and Medical Research Council Australia (Project grant #572548). TS was supported by a Research Fellowship of the Deutsche Forschungsgemeinschaft (STR1022/1-1) and an International Postgraduate Research Scholarship of the University of Western Australia. DPB is supported by a National Health and Medical Research Council Clinical Career Development Fellowship and the research was supported by the Victorian Government's Operational Infrastructure Support Program. BRAHMS (Thermo Fisher Scientific) provided the procalcitonin assays without charge. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.