Journal article
Histologic chorioamnionitis is associated with reduced risk of late-onset sepsis in preterm infants
T Strunk, D Doherty, A Jacques, K Simmer, P Richmond, R Kohan, A Charles, D Burgner
Pediatrics | AMER ACAD PEDIATRICS | Published : 2012
Abstract
BACKGROUND: Histologic chorioamnionitis (HCA) is implicated in the onset of preterm labor and delivery. Chorioamnionitis is a known risk factor for early-onset sepsis and may modulate postnatal immunity. Preterm infants are at greatly increased risk of late-onset sepsis (LOS), particularly with coagulase-negative staphylococci (CoNS), but the impact of HCA on the risk of LOS is unknown. METHODS: Eight hundred thirty-eight preterm infants born at <30 weeks gestational age at a single tertiary center were included. Histologic examination of placenta and extraplacental membranes was performed, and clinical data were extracted from hospital databases. The influence of HCA on the incidence of ear..
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Awarded by National Health and Medical Research Council, Australia
Awarded by Deutsche Forschungsgemeinschaft
Funding Acknowledgements
We thank all participating families and the clinical and scientific contributions of the Vaccine Trials Group; all midwifery, obstetric, and neonatal staff at King Edward Memorial Hospital; and the Department of Pathology at Princess Margaret Hospital for Children for their assistance in the completion of this study. We also thank Dr Anthony Keil and staff of the Department of Microbiology, PathWest Laboratory Medicine Western Australia, King Edward Memorial Hospital for Women & Princess Margaret Hospital for Children for performing the placental cultures and critical review of the manuscript. This study was supported by Princess Margaret Hospital, Women's and Infants' Research Foundation (Western Australia), Clive and Vera Ramaciotti Medical Research Foundation, University of Western Australia, Rebecca Cooper Medical Research Foundation, Channel 7 Telethon, European Society for Pediatric Infectious Diseases and the National Health and Medical Research Council (project grant 513847), Australia. Dr Strunk was supported by the Deutsche Forschungsgemeinschaft (STR1022/1-1) and by an International Postgraduate Research Scholarship of the University of Western Australia. Dr Burgner is supported by a Clinical Career Development Award from the National Health and Medical Research Council, Australia. This research was supported by the Victorian Government's Operational Infrastructure Support Program.