Journal article
Genome-wide linkage and association mapping identify susceptibility alleles in ABCC4 for Kawasaki disease
CC Khor, S Davila, C Shimizu, S Sheng, T Matsubara, Y Suzuki, JW Newburger, A Baker, D Burgner, W Breunis, T Kuijpers, VJ Wright, M Levin, ML Hibberd, JC Burns
Journal of Medical Genetics | B M J PUBLISHING GROUP | Published : 2011
Abstract
Background: Kawasaki disease (KD) is a self limited vasculitis in which host genetics plays a prominent role. To further the understanding of the role of host genetics in KD, a three-stage genetic study was conducted that began with a family linkage study and ultimately involved more than 3000 individuals to identify new genetic contributions to KD susceptibility. Methods and results: A 26-family linkage study followed by fine mapping was performed in a cohort of 1284 KD subjects and their family members (total 3248 individuals). Suggestive evidence of disease linkage (logarithm of odds (LOD) ≥3.0, p<1.00×10-4) was found for five genomic locations (Chr 3q, 4q, 10p, 13q, 21q). Two of these lo..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
We thank all individuals with Kawasaki disease and their families for participating in this study. We thank Wee-Yang Meah, Hong-Boon Toh, Xiaoyin Chen, Khai-Koon Heng, Chang-Hua Wong, Dennis EK Tan, Nicholas JW Tay, Poh-Ling Ng, Sherrina HY Chen, and Sigeeta Rajaram for technical support and expertise. This work supported in part by a grant (HL69413) from the National Institutes of Health, National Heart, Lung, Blood Institute (to JCB), the Raine Medical Research Foundation, the Ada Bartholomew Medical Research Trust, the University of Western Australia, the National Heart Foundation of Australia, and the Agency for Science, Technology and Research, Singapore.