Journal article
Transforming growth factor-β signaling pathway in patients with Kawasaki disease
C Shimizu, S Jain, ML Hibberd, KO Lin, D Molkara, JR Frazer, S Sun, AL Baker, JW Newburger, AH Rowley, ST Shulman, S Davila, D Burgner, WB Breunis, TW Kuijpers, VJ Wright, M Levin, H Eleftherohorinou, L Coin, SJ Popper Show all
Circulation Cardiovascular Genetics | Published : 2011
Abstract
Background-Transforming growth factor (TGF)-β is a multifunctional peptide that is important in T-cell activation and cardiovascular remodeling, both of which are important features of Kawasaki disease (KD). We postulated that variation in TGF-β signaling might be important in KD susceptibility and disease outcome. Methods and Results - We investigated genetic variation in 15 genes belonging to the TGF-β pathway in a total of 771 KD subjects of mainly European descent from the United States, the United Kingdom, Australia, and the Netherlands. We analyzed transcript abundance patterns using microarray and reverse transcriptase-polymerase chain reaction for these same genes, and measured TGF-β..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
This work was supported in part by grants from the National Institutes of Health, National Heart, Lung, Blood Institute (HL074864, HL091494, HL69413, and a U54 grant HL108460 awarded to Dr Burns and T35 HL007491-28, NIH Short-term Research Training Grant, awarded to Dr Lin) and by funding from the Singapore Agency for Science Technology and Research (A*STAR) to Dr Hibberd for the work at the Genome Institute Singapore; by funding from London Law Trust, Sir Samuel Scott of Yews Trust, University of Western Australia, National Heart Foundation Australia, Princess Margaret Hospital Perth, Raine Medical Research Foundation, and Ada Bartholomew Medical Research Trust to Dr Burgner.