Journal article

TLR2 Mediates Recognition of Live Staphylococcus epidermidis and Clearance of Bacteremia

Tobias Strunk, Melanie R Power Coombs, Andrew J Currie, Peter Richmond, Douglas T Golenbock, Liat Stoler-Barak, Leighanne C Gallington, Michael Otto, David Burgner, Ofer Levy

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2010

Abstract

BACKGROUND: Staphylococcus epidermidis (SE) is a nosocomial pathogen that causes catheter-associated bacteremia in the immunocompromised, including those at the extremes of age, motivating study of host clearance mechanisms. SE-derived soluble components engage TLR2; but additional signaling pathways have also been implicated, and TLR2 can play complex, at times detrimental, roles in host defense against other Staphylococcal spp. The role of TLR2 in responses of primary blood leukocytes to live SE and in clearance of SE bacteremia, the most common clinical manifestation of SE infection, is unknown. METHODOLOGY/PRINCIPAL FINDINGS: We studied TLR2-mediated recognition of live clinical SE strai..

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Grants

Awarded by National Institute of Allergy and Infectious Diseases, National Institutes of Health


Awarded by Deutsche Forschungsgemeinschaft


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

Financial support: National Institute of Allergy and Infectious Diseases, National Institutes of Health RO1 AI067353-01A1 (O. L.); Princess Margaret Hospital, Women's and Infants' Research Foundation Western Australia, Clive and Vera Ramaciotti Medical Research Foundation, U. Western Australia, Rebecca Cooper Medical Research Foundation, Channel7 Telethon, European Society for Paediatric Infectious Diseases and the National Health and Medical Research Council, Australia (T. S., A. C., P. R., and D. B.); Intramural Research Program of the National Institute of Allergy and Infectious Diseases, U.S. National Institutes of Health (M. O.). T. S. was supported by a Research Fellowship of the Deutsche Forschungsgemeinschaft (STR1022/1-1) and an International Postgraduate Research Scholarship of the University of Western Australia. Support was also provided by fellowships from the Harvard Club of Australia (O. L.), Canadian Institutes of Health Research (M. C.) and the Children's Health Research Foundation of Western Australia (A. J. C.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.