Journal article

Central relaxin-3 receptor (RXFP3) activation decreases anxiety- and depressive-like behaviours in the rat

Philip J Ryan, Elena Buechler, Fazel Shabanpoor, Mohammed Akhter Hossain, John D Wade, Andrew J Lawrence, Andrew L Gundlach



Relaxin-3 is a recently discovered neuropeptide and the results of earlier anatomical and pharmacological studies suggest it plays a physiological role in modulating functions such as arousal, learning and memory, food intake and neuroendocrine homeostasis. Relaxin-3 is also postulated to modulate affective behaviour, based on high densities of the relaxin-3 G-protein coupled receptor (RXFP3) in brain areas involved in stress and mood/anxiety, including the central amygdala, bed nucleus of the stria terminalis and hypothalamic paraventricular nucleus (PVN); and strong activation of relaxin-3 neurons by stressors, via activation of corticotropin-releasing factor receptor-1 (CRF1). This study ..

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Funding Acknowledgements

This research was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia, the Pratt Foundation and the Besen Family Foundation, and the Florey Neuroscience Institutes Trust Foundation. During these studies, P.J.R. was the recipient of an Australian Postgraduate Award and a Dowd Foundation Neuroscience Scholarship. E.B. was a visiting undergraduate scholar from the University of Applied Sciences, Gelsenkirchen, Germany. F.S. and M.A.H. were Florey Neuroscience Institutes Foundation Fellows and J.D.W., A.J.L. and A.L.G. are NHMRC Research Fellows. The authors wish to thank Brett Purcell and members of the Florey Integrated Neuroscience Facilities (INF) for their advice and assistance with behavioural testing, and Elena Krstew for help with statistical analysis.