Journal article

Global Changes in the Mammary Epigenome Are Induced by Hormonal Cues and Coordinated by Ezh2

Bhupinder Pal, Toula Bouras, Wei Shi, Francois Vaillant, Julie M Sheridan, Naiyang Fu, Kelsey Breslin, Kun Jiang, Matthew E Ritchie, Matthew Young, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Cell Reports | CELL PRESS | Published : 2013


Awarded by Australian National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

We are very grateful to A. Tarakovsky for providing floxed Ezh2 mice and J. Adams for critical review of the manuscript. We also thank GeneWorks for library preparation and sequencing of ChIP samples; D. Wu for help with bioinformatic analysis; E. Nolan, T. McLennan, B. Capaldo, and T. Ward for expert help; C. Clarke, K. Simpson, D. Reinberg, G. McArthur, and B. Sarcevic for reagents; and the animal, FACS, and histology facilities at WEHI. We thank C. Clarke, J. Carroll, and S. Clark for discussions. This work was supported by the Australian National Health and Medical Research Council (NHMRC) #461224, #461221, #637307, #637308, #1016701, and Australia Fellowship (to J.E.V.); NHMRC #490037 (to G.K.S.); the WEHI Genomics Fund; NHMRC IRIISS; the Victorian State Government through VCA funding of the Victorian Breast Cancer Research Consortium and Operational Infrastructure Support; and the ACRF. B.P. and T.B. were supported by NHMRC Biomedical and National Breast Cancer Foundation (Australia) Fellowships, respectively.