Journal article
A diagnosis of the metabolic syndrome in youth that resolves by adult life is associated with a normalization of high carotid intima-media thickness and type 2 diabetes mellitus risk: The bogalusa heart and cardiovascular risk in young finns studies
CG Magnussen, J Koskinen, M Juonala, W Chen, SR Srinivasan, MA Sabin, R Thomson, MD Schmidt, QM Nguyen, JH Xu, MR Skilton, M Kähönen, T Laitinen, L Taittonen, T Lehtimäki, T Rönnemaa, JSA Viikari, GS Berenson, OT Raitakari
Journal of the American College of Cardiology | ELSEVIER SCIENCE INC | Published : 2012
Abstract
Objectives: The aim of this study was to examine the effect of resolution from metabolic syndrome (MetS) between youth and adulthood on carotid artery intima-media thickness (IMT) and type 2 diabetes mellitus (T2DM). Background: Published findings demonstrate that youth with MetS are at increased risk of cardio-metabolic outcomes in adulthood. It is not known whether this risk is attenuated in those who resolve their MetS status. Methods: Participants (n = 1,757) from 2 prospective cohort studies were examined as youth (when 9 to 18 years of age) and re-examined 14 to 27 years later. The presence of any 3 components (low high-density lipoprotein cholesterol, high triglycerides, high glucose,..
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Awarded by National Institute of Child Health and Human Development
Funding Acknowledgements
From the *Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; dagger Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia; double dagger Department of Medicine, Turku University Hospital, Turku, Finlan; Tulane Center for Cardiovascular Health, Tulane University, New Orleans, Louisiana; parallel to Murdoch Childrens Research Institute, Melbourne, Australia; Department of Kinesiology, University of Georgia, Athens, Georgia; #The Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, University of Sydney, Sydney, Australia; **Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland; dagger dagger Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland; Department of Pediatrics, Vaasa Central Hospital, Vaasa, Finland; double dagger double dagger Department of Pediatrics, University of Oulu, Oulu, Finland; parallel to parallel to Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland; and the Department of Clinical Physiology, Turku University Hospital, Turku, Finland. The Bogalusa Heart Study was supported by Grants HD-061437 and HD-062783 from the National Institute of Child Health and Human Development and AG-16592 from the National Institute on Aging. The Cardiovascular Risk in Young Finns study was financially supported by the Academy of Finland (Grants 117797, 126925, and 121584), the Social Insurance Institution of Finland, the Turku University Foundation, Special Federal Grants for the Turku, Tampere, and Kuopio University Central Hospital, the Juho Vainio Foundation, the Finnish Foundation of Cardiovascular Research, the Finnish Cultural Foundation, and the Orion Farmos Research Foundation. The contribution of Dr. Magnussen to this paper was supported in part by The Finnish Foundation for Cardiovascular Research; and holds a National Health and Medical Research Council Early Career Fellowship (Public Health Fellowship, APP1037559). Dr. Lehtimaki is supported in part by the Emil Aaltonen Foundation. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.