Virotherapy, gene transfer and immunostimulatory monoclonal antibodies
Jose I Quetglas, Liza B John, Michael H Kershaw, Luis Alvarez-Vallina, Ignacio Melero, Phillip K Darcy, Cristian Smerdou
ONCOIMMUNOLOGY | TAYLOR & FRANCIS INC | Published : 2012
Malignant cells are susceptible to viral infection and consequent cell death. Virus-induced cell death is endowed with features that are known to stimulate innate and adaptive immune responses. Thus danger signals emitted by cells succumbing to viral infection as well as viral nucleic acids are detected by specific receptors, and tumor cell antigens can be routed to professional antigen-presenting cells. The anticancer immune response triggered by viral infection is frequently insufficient to eradicate malignancy but may be further amplified. For this purpose, transgenes encoding cytokines as co-stimulatory molecules can be genetically engineered into viral vectors. Alternatively, or in addi..View full abstract
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Awarded by Spanish Health Ministry
Awarded by Spanish Economy Ministry
Financial support was from the Spanish Health Ministry (PI11/02190), Spanish Economy Ministry (SAF2011-22831), CIMA-UTE, the National Health and Medical Research Council (NHMRC) of Australia, Cancer Council of Victoria and the Susan Komen Breast Cancer Foundation. M.H.K. and P.K.D. were supported by a NHMRC Senior Research Fellowship and Career Development Award respectively.