Journal article
Electroretinography in streptozotocin diabetic rats following acute intraocular pressure elevation
Kenichi Kohzaki, Algis J Vingrys, James A Armitage, Bang V Bui
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | SPRINGER | Published : 2013
Abstract
BACKGROUND: We consider whether pre-existing streptozotocin induced hyperglycemia in rats affects the ability of the eye to cope with a single episode of acute intraocular pressure (IOP) elevation. METHODS: Electroretinogram (ERG) responses were measured (-6.08 to 1.92 log cd.s.m(-2)) in anaesthetized (60:5 mg/kg ketamine:xylazine) dark-adapted (>12 h) adult Sprague-Dawley rats 1 week after a single acute IOP elevation to 70 mmHg for 60 min. This was undertaken in rats treated 11 weeks earlier with streptozotocin (STZ, n = 12, 50 mg/kg at 6 weeks of age) or citrate buffer (n = 12). ERG responses were analyzed to derive an index of photoreceptor (a-wave), ON-bipolar (b-wave), amacrine (oscill..
View full abstractRelated Projects (3)
Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported by a National Health and Medical Research Council Grants 400127 (BVB) and 350224 (AJV). We the authors have full control of all primary data and they agree to allow Graefe's Archive for Clinical and Experimental Ophthalmology to review this data upon request.