Journal article
The Peri/postnatal epigenetic twins study (PETS)
YJ Loke, B Novakovic, M Ollikainen, EM Wallace, MP Umstad, M Permezel, R Morley, AL Ponsonby, L Gordon, JC Galati, R Saffery, JM Craig
Twin Research and Human Genetics | Published : 2013
DOI: 10.1017/thg.2012.114
Abstract
The Peri/postnatal Epigenetic Twins Study (PETS) is a longitudinal cohort of 250 pairs of Australian twins and their mothers, who were recruited mid-way through pregnancy from January 2007 to September 2009. The study is centered on the developmental origins of health and disease paradigm (DOHaD) in which an adverse intrauterine environment predisposes the individual to complex disease in later life by reducing growth in utero and adversely altering developmental plasticity. Data concerning diet and lifestyle were collected from mothers during pregnancy, and samples of plasma and serum taken at 28 weeks' gestation. We attended 75% of all births, at which time we collected multiple biological..
View full abstractGrants
Awarded by Australian National Health and Medical Research Council
Awarded by Bonnie Babes Foundation
Awarded by Financial Markets Foundation for Children
Funding Acknowledgements
We thank all of the families who participated in the PETS study; our tireless research assistants, Sarah Healy, Tina Vaiano, Nicole Brooks, Jennifer Foord, Sheila Holland, Ann Krastev, and Joanne Mockler; Anna Czajko, Mandy Parkinson-Bates, Hong Kiat Ng, Nur Khairunnisa Abdul Aziz, and Noha Ahmed Nasef for technical assistance; bioinformaticians Gordon Smyth, Alicia Oshlack, Katrina Bell, and Katherine Smith; phlebotomists Bernie McCudden, Judith Spottswood, Erin Hill, and staff from Royal Childrens Hospital Pathology Collection; and Geraldine McIlroy and Hien Nguyen for their administrative assistance. This work was supported by grants from the Australian National Health and Medical Research Council (grant numbers 437015 and 607358 to JC, and RS), the Bonnie Babes Foundation (grant number BBF20704 to EJ), the Sigrid Juselius Foundation (to MO), the Academy of Finland (to MO), the Finnish Cultural Foundation (to MO), the Financial Markets Foundation for Children (grant no. 032-2007), and by the Victorian Government's Operational Infrastructure Support Program.