Journal article

Evaluation of ADAM-12 as a Diagnostic Biomarker of Ectopic Pregnancy in Women with a Pregnancy of Unknown Location

Andrew W Horne, Jeremy K Brown, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2012

Abstract

BACKGROUND: Ectopic pregnancy (EP) remains the most life-threatening acute condition in modern gynaecology. It remains difficult to diagnose early and accurately. Women often present at emergency departments in early pregnancy with a 'pregnancy of unknown location' (PUL) and diagnosis/exclusion of EP is challenging due to a lack of reliable biomarkers. Recent studies suggest that serum levels of a disintegrin and metalloprotease protein-12 (ADAM-12) can be used differentiate EP from viable intrauterine pregnancy (VIUP). Here we describe a prospective study evaluating the performance of ADAM-12 in differentiating EP from the full spectrum of alternative PUL outcomes in an independent patient ..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by United Kingdom Medical Research Council (MRC)


Awarded by Medical Research Council


Funding Acknowledgements

The study was supported by the Australian National Health and Medical Research Council (#1008276; #606611) and by the United Kingdom Medical Research Council (MRC G0802808). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.