A neurodevelopnnental basis for BECTS: Evidence from structural MRI

Heath R Pardoe; Anne T Berg; John S Archer; Robert K Fulbright; Graeme D Jackson

Journal article

A neurodevelopnnental basis for BECTS: Evidence from structural MRI

Heath R Pardoe, Anne T Berg, John S Archer, Robert K Fulbright, Graeme D Jackson

EPILEPSY RESEARCH | ELSEVIER SCIENCE BV | Published : 2013

DOI: 10.1016/j.eplepsyres.2012.11.008

Abstract

PURPOSE: BECTS (benign epilepsy with centro-temporal spikes) is one of the most common childhood-onset epilepsy syndromes. We investigated quantitative evidence for brain morphological variation associated with BECTS to provide insights into the neuroanatomical basis of this disorder. METHODS: Three independent BECTS groups were imaged at different stages: (a) near onset (n=16, mean age 9.3±1.6 years), (b) ~9 years after onset (n=9, mean age 15.8±2.3 years), and (c) ~15 years after onset (n=10, mean age 22.7±2.7 years). Age-matched controls were imaged with each group. Whole brain T1-weighted MRI was acquired. Voxel-based morphometry (groups a-c) and cortical thickness analyses (groups b and..

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University of Melbourne Researchers

John Archer Author Medicine - Austin Health

Graeme Jackson Author Florey Department of Neuroscience and Mental Health

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Grants

Awarded by National Institutes of Health

Awarded by National Health and Medical Research Council, Australia

Awarded by National Health and Medical Research Council Australia

Awarded by Victorian Life Sciences Computational Initiative, Australia

Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

Funding Acknowledgements

Study funding: National Institutes of Health (NS-R37-31146, PI AT Berg), National Health and Medical Research Council, Australia (project grant 318900), National Health and Medical Research Council Australia (program grant 400121), Victorian Life Sciences Computational Initiative, Australia (VR0056), Victorian Government's Operational Infrastructure Support Program, Australia.